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Drugs
and Their Effects
Drug Definitions Factors Governing the Intensity of Effects Drug Use and Drug Dependency Popular Myths Drugs of Concern Alcohol Cannabis Cocaine Stimulants Other than Cocaine Narcotics Hallucinogens Barbiturates Solvents Tranquillizers Performance Enhancing Drugs |
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The word Drug is defined as "any substance other than food that can affect the way your mind and body work." There are hundreds of different drugs, each with its particular effect on the body's nervous system. Narcotics are a series of drugs that affect the mind, causing mental changes. The United States Government will not allow any new drug to be prescribed by a doctor or sold by a pharmacist until the drug has been thoroughly tested and proven to be medically safe. These tests take as long as years before they are approved for use by the public; and even after they have been approved and sold for years, serious side effects may appear and the drug is removed and discarded for any further medical use. Unstable
drugs, referred to on the streets as Crack, PCP, Ice, LSD, Speed and
many others, are made up of several chemical substances which are
made illegally in hideaways without proper equipment or skills to
carefully measure exact proportions - resulting in a drug that no
one knows what the after-effects will be.
It is not east to arrive at definitions that are commonly agreed upon in the substance abuse field. This is because the pharmacological actions of drugs on the human system are very complex and not yet fully understood. Moreover, individuals will experience different drug effects depending on physical and psychological make-up. The wide range of substances used and society's changing attitudes towards various substances also create challenges in this area. Nonetheless, research and practice in this field are leading to greater agreement on drug definitions. Drug
Drug
Abuse Tolerance
Dependence
Physical - The user's body has become so accustomed to the presence of the drug that when it is no longer used, withdrawal symptoms occur. These may be mild, such as sneezing and a runny nose, to very severe, such as potentially fatal convulsions. The severity of withdrawal increases with the level of the drug taken and the duration of abuse. Psychological - Users, though not experiencing withdrawal symptoms upon cessation of use, nonetheless believe that they cannot function without the drug and crave it. Addiction - Traditionally, this term has been synonymous with physical dependence and full-fledged withdrawal symptoms. Though the term is still widely used, most specialists prefer the term "drug dependency." What is important to remember is that contrary to popular opinion, it does not matter a great deal whether a user is physically or psychologically dependent. Both forms of dependency indicate a serious loss of control. Factors Governing the Intensity of Effects Drugs in the same category have similar effects, but the potency of the drug varies with the particular compound. For instance, heroin is stronger than morphine and morphine is stronger than codeine though they are all derived from the opium poppy. The symptoms and the effects of using a given drug can vary considerably with the dose taken; this is especially true of short-term effects. Concentration
in the Body The rate of absorption depends on the concentration of the drug (dose and purity), its degree of fat solubility, the surface area of absorption, and the diffusion distance, i.e., the number of membranes it must cross before reaching the bloodstream and the central nervous system (principally, the brain). Administration
of the Drug (1) Oral: This is the most common method. It can be used for pills, capsules, liquids, tablets, and powders. Drugs taken by mouth are absorbed principally through the small intestine, less so through the stomach walls. Drugs taken by mouth tend to be absorbed slowly, in part because they can be diluted by the presence of food in the stomach. Food can also coat the drug so that it will pass out of the body through the feces without having been absorbed. Oral administration usually means a less intense drug effect, particularly for major depressants or stimulates of the central nervous system. (2) Across Mucous Membranes: The mucous membranes are the moist surfaces of the nose, sinus cavities, mouth, throat, rectum, and vagina. The rate of absorption tends to be rapid because mucous membranes are thin and have a greater blood supply than the skin. There are two major ways a drug can enter the body through the mucous membranes. Drugs such as cocaine, amyl nitrate ("poppers"), and tobacco snuff can be sniffed ("snorted"). This leads to rapid and effective absorption across the mucous membranes of the nose. Inhalation of a drug also means the drug enters the body rapidly and effectively, this time across the mucous membranes of the alveoli, the tiny cavities in the lung where the exchange of gasses takes place. The drug must be in the form of a gas (such as the vapours of glue or solvents), fine liquid drops, or fine particles of matter suspended in a gas (such as tobacco or cannabis smoke). It should be noted that glue vapours are inhaled and are, therefore, absorbed through the lungs; technically, the term "glue sniffing" is incorrect. (3) Parenteral (injection): There are three methods of injecting a drug, and all lead generally to more rapid absorption and intense effects than other forms of drug administration. They also mean a much more serious risk of infection due to the sharing of needles. Two infections often associated with the injection of drugs due to the sharing of needles are HIV and hepatitis B. Subcutaneous injections ("skin popping") involve injecting the drug just under the skin. This is normally seen among beginning injection users because it is not difficult to do and is less traumatizing psychologically. Intramuscular injections involve a deeper injection into tissue mass. Localized pain is the major drawback to this type of injection, though there is the advantage that the needle can be inserted through the clothing and the injection can therefore be given rapidly. Intramuscular injection is a common method of administration by users of anabolic steroids. Intravenous injections ("mainlining") lead to extremely rapid absorption and intense effects because the drug is injected directly into the bloodstream through a vein. It is often the preferred form of drug administration for experienced users. Distribution
in the Body Elimination
from the Body Volatile drugs, such as solvents, are excreted through the breath. In the case of alcohol, however, the breath is a very minor method of elimination. Drugs can also be metabolized. The drug is transformed by enzymes into by-products called "metabolites." Most drug metabolism occurs in the liver and is a very complex process. In the case of THC (the main psychoactive ingredient of cannabis), for instance, which is highly fat soluble, the substance must be broken down into 25 metabolites. It should be noted that repeated use of drugs metabolized by the liver leads to more rapid metabolism. This is a major factor in bringing about drug tolerance Multiple-drug
Use There are many patterns of drug use and it is difficult to predict the course of a person's drug use. A small proportion of users will become drug dependent; however, the actual course followed, and the outcome, will depend on many factors, including: drug used
First
phase: experimentation It is during this first phase that intervention is most timely, before problems emerge. Unfortunately, it is also during the first phase that intervention is most difficult, because the risks of drug use are often not apparent to the user. Second
phase: the emergence of dependency Users may easily convince themselves that everything is still fine, that they are not physically ill, depressed, or otherwise psychologically troubled. They may even still be producing relatively well at work or at school. This phase, depending on the factors listed above, can last indefinitely. Many "second-phase users" can be found in the workplace, where they may seem to be relatively immune to any ill effects. Third
phase: dependence syndrome There are many myths and fantasies that encourage people to experiment with drugs. Here are some of the most popular. "It's
only alcohol, I don't do drugs" "It's
an aphrodisiac" The evidence is quite strong that regular drug users are far more preoccupied with obtaining a steady supply of drugs than with a healthy sex life. The drugs that are used generally have such a powerful effect on the brain that they replace the sex drive with an artificial desire based on craving the drug. "I
Just want to try it out" Street drugs are notorious for being diluted with chemicals that can be extremely dangerous. Drug sellers are not concerned with the health of users. Another problem with experimentation is that users are convinced they will never become dependent. Addicted people, no doubt, start off "just trying it out." "This
is the only stuff I'm using" In using an illicit drug on an experimental basis, the user may come into contact with other people who use drugs and be offered other substances. Drug involvement that begins with the use of tobacco and alcohol may go on to illicit substances such as marihuana and cocaine. This is particularly true for users who start at a young age. "It
will never happen to me" "Impaired
driving = drinking and driving" Alcohol The use of alcohol before and during the workday has been documented in an earlier section. Many skills and cognitive* processes begin to deteriorate at a Blood Alcohol Content (BAC) of 50 mg of alcohol per 100 ml of blood. (In America, a driver is considered to be legally impaired at a BAC of 80 mg of alcohol per 100 ml of blood). In practical terms, this means that an occasional drinker weighing 160-180 pounds (73-82 kilograms) who has two drinks within one hour on an empty stomach would be at least mildly impaired. Major functional
effects *Cognition is a term widely used in psychology and generally means the process of knowing, or understanding, what one perceives. Signs of
use Cannabis (marihuana,
hashish) Major
functional effects Cocaine Though the coca leaf, and its extract cocaine hydrochloride, have been used for more than four thousand years, abuse in the workplace in North America is relatively recent. Partly because of its very high cost and alleged popularity among high-profile personalities, the use of cocaine in the workplace was at one time associated with the affluent, executive-level positions. The use of cocaine has, in the past decade, spread to other white collar, blue collar and student populations. The principal danger with cocaine is that its effects are intense but of short duration; over time, use becomes very frequent and psychological dependency extreme. "Crack" is the street name for a more purified form of cocaine that is smoked. It is extremely addictive, and because it is prevalent in various centres in America, there is considerable concern about this form of the drug. Major functional
effects
Stimulants Other than Cocaine (amphetamines,
methamphetamine, methylenedioxymethamphetamine, Methedrine, Dexedrine,
Ritalin, etc.) "Ice" is a crystal form of a methamphetamine that can be smoked. The availability of a smokeable form increases the risk of abuse because it is delivered to the brain so rapidly and efficiently. MDMA, methylenedioxymethamphetamine, ("Ecstasy") is another amphetamine derivative. Major
functional effects Narcotics (morphine,
heroin, codeine, methadone, Demerol*, Dilaudid*, etc.) Major
functional effects (LSD, STP,
MDA, DMT, psilocybin, mescaline, phencyclidine, etc.) Major
functional effects Barbiturates (Nembutal,
Seconal, phenobarbital, Tuinal, Dexamel, Mandrax, Quaalude, etc.) Major
functional effects Solvents (cleaning
fluids, nail polish remover, gasoline, household cement, lacquer thinners,
lighter fluids, plastic cements, [naphtha, acetone, toluene, benzene],
etc.) Major
functional effects Tranquillizers (Librium,
Valium, Mogadon, Tranxene, etc.) Major
functional effects Performance Enhancing Drugs Anabolic/androgenic steroids (Anvar, Deca Durabolin testosterone, Winstrol-V, etc.) are chemically manufactured derivatives of the male sex hormone, testosterone. No steroid is purely androgenic (masculinizing) or purely anabolic (growing or building). Therefore steroid use results in some combination of these effects. Anabolic steroids comprise one group of these hormonal drugs. Anabolic steroids are designed to mimic the body-building traits of testosterone to build up the body to perform better in sports and to change the muscular appearance of the body. These drugs are also used to increase muscle mass in occupations where physical size contributes to job performance (23). On the psychological side, many users report "feeling good" about themselves while on anabolic steroids. When the drugs are stopped there are reported wide mood swings ranging from periods of violent episodes known as " 'roid rages " to depression. Other drugs abused by athletes include stimulants, diuretics, beta blockers and pain killers. While in the past, the use of performance-enhancing drugs was limited to elite athletes, it is now understood to be a social problem involving a range of athletes as well as those interested in body image. In a recent national study of 11 to 18 years old, only 4% had never heard of anabolic steroids; 50% of females and 67% of males believed that anabolic steroids would enhance performance; and 1.5% of females and 4.1% of males have used steroids. Major
functional effects for males
Employed drug abusers cost their employers about twice as much in medical and worker compensation claims as their drug-free coworkers. A study prepared by The Lewin Group for the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism estimated the total economic cost of alcohol and drug abuse to be $245.7 billion for 1992. Of this cost, $97.7 billion* was due to drug abuse. This estimate includes substance abuse treatment and prevention costs as well as other healthcare costs, costs associated with reduced job productivity or lost earnings, and other costs to society such as crime and social welfare. The study also determined that these costs are borne primarily by governments (46 percent), followed by those who abuse drugs and members of their households (44 percent). The 1992 cost estimate has increased 50 percent over the cost estimate from 1985 data. The four primary contributors to this increase were (1) the epidemic of heavy cocaine use (2) the HIV epidemic (3) an eightfold increase in state and Federal incarcerations for drug offenses, and (4) a threefold increase in crimes attributed to drugs. More than half of the estimated costs of drug abuse were associated with drug-related crime. These costs included lost productivity of victims and incarcerated perpetrators of drug- related crime (20.4 percent); lost legitimate production due to drug-related crime careers (19.7 percent); and other costs of drug-related crime, including Federal drug traffic control, property damage, and police, legal, and corrections services (18.4 percent). Most of the remaining costs resulted from premature deaths (14.9 percent), lost productivity due to drug-related illness (14.5 percent), and healthcare expenditures (10.2 percent). The White House Office of National Drug Control Policy (ONDCP)** conducted a study to determine how much money is spent on illegal drugs that otherwise would support legitimate spending or savings by the user in the overall economy. ONDCP found that, between 1988 and 1995, Americans spent $57.3 billion on drugs, broken down as follows: $38 billion on cocaine, $9.6 billion on heroin, $7 billion on marijuana, and $2.7 billion on other illegal drugs and on the misuse of legal drugs * This estimate includes illicit drugs and other drugs taken for non-medical purposes. It does not include nicotine. --------------------------------------------------------------------------------
The White House Office of National Drug Control Policy.A study prepared by The Lewin Group for the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism estimated the total economic cost of alcohol and drug abuse to be $245.7 billion for 1992. Of this cost, $97.7 billion* was due to drug abuse. This estimate includes substance abuse treatment and prevention costs as well as other healthcare costs, costs associated with reduced job productivity or lost earnings, and other costs to society such as crime and social welfare. The study also determined that these costs are borne primarily by governments (46 percent), followed by those who abuse drugs and members of their households (44 percent). The 1992 cost estimate has increased 50 percent over the cost estimate from 1985 data. The four primary contributors to this increase were (1) the epidemic of heavy cocaine use (2) the HIV epidemic (3) an eightfold increase in state and Federal incarcerations for drug offenses, and (4) a threefold increase in crimes attributed to drugs. More than half of the estimated costs of drug abuse were associated with drug-related crime. These costs included lost productivity of victims and incarcerated perpetrators of drug- related crime (20.4 percent); lost legitimate production due to drug-related crime careers (19.7 percent); and other costs of drug-related crime, including Federal drug traffic control, property damage, and police, legal, and corrections services (18.4 percent). Most of the remaining costs resulted from premature deaths (14.9 percent), lost productivity due to drug-related illness (14.5 percent), and healthcare expenditures (10.2 percent). The White House Office of National Drug Control Policy (ONDCP)** conducted a study to determine how much money is spent on illegal drugs that otherwise would support legitimate spending or savings by the user in the overall economy. ONDCP found that, between 1988 and 1995, Americans spent $57.3 billion on drugs, broken down as follows: $38 billion on cocaine, $9.6 billion on heroin, $7 billion on marijuana, and $2.7 billion on other illegal drugs and on the misuse of legal drugs * This estimate includes illicit drugs and other drugs taken for non-medical purposes. It does not include nicotine. --------------------------------------------------------------------------------
U.S. Department
of Health and Human Services ·National Institutes of Health.
Resource Links: http://165.112.78.61/Infofax/treatmenttrends.html http://165.112.78.61/DrugPages/Stats.html
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